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Analytical approaches

Cavalloro Valeria, EXTRACTION AND CHARACTERIZATION OF (S)-USNIC ACID FROM Cladonia foliacea

Cirrincione Marco, INNOVATIVE ATR-FTIR METHOLOGY FOR CANNABIS PRODUCT DISCRIMINATION

Esposito Salsano Jasmine, IMMUNOMODULATORY PROPERTIES OF BIOMEDICAL DEVICES BASED ON BIOPOLYMERS INCORPORATING OLIVE LEAF EXTRACT

Marasca Camilla, A MICROFLUIDIC-BASED DBS PROCEDURE FOR THE ANALYSIS OF CNS DRUGS BY UHPLC-HRMS

Rinaldi Francesca, DEVELOPMENT OF PAPAIN-IMERs FOR THE STRUCTURAL CHARACTERIZATION OF MONOCLONAL ANTIBODIES

Varfaj Ina, ENANTIOSEPARATION OF ILLICIT FENTANYLS UNDER POLAR-IONIC CONDITIONS

 

Antiinfective

Cianciusi Annarita, NEW POTENTIAL ANTI-FLU AGENTS ACTING BY DISRUPTING THE PA-PB1 INTERACTION OF VIRAL POLYMERASE

Zhou Ruyao, DESIGN, SYNTHESIS AND CHARACTERIZATION OF NEW BORONIC ACIDS “CO-DRUG” INHIBITORS OF SERINE AND METALLO-β-LACTAMASES

Bassanini Ivan, NON-ATP-COMPETITIVE INHIBITION OF THE MOLECULAR CHAPERON HSP90 FOR THE TARGET-ORIENTED DEVELOPMENT OF NOVEL ANTIPROTOZOAL AGENTS

Di Chio Carla, DEVELOPMENT OF NOVEL DIPEPTIDE NITRILES AS INHIBITORS OF RHODESAIN OF TRYPANOSOMA BRUCEI RHODESIENSE

Introvigne Maria Luisa, CHIRAL SULFONAMMIDO-BORONIC ACIDS AS INHIBITORS OF CLASS C AND CLASS D b-LACTAMASES: DESIGN, SYNTHESIS AND PRELIMINARY DATA

Szczepanska Anna, DESIGN, SYNTHESIS AND ACTIVITY OF SARS-COV-2 S PROTEIN – HUMAN ACE2 INTERACTION INHIBITORS BASED ON MINIPROTEINS

Świerczek Natalia, DESIGN, SYNTHESIS, INHIBITORY ACTIVITY AND NMR STUDIES OF HRLICAL PEPTIDE FOLDAMERS AGAINST SARS-COV-2 PROTEIN S – HUMAN ACE2 INTERACTION

Baldassarri Cecilia, SYNTHESIS AND ANTI-TRYPANOSOMAL ACTIVITY OF PYRAZOLONE-BASED HYDRAZONES ZINC(II) COMPLEXES

Mancuso Francesca, SYNTHESIS, INHIBITORY ACTIVITY AND IN SILICO MODELING OF NOVEL INHIBITORS OF CARBONIC ANHYDRASES EXPRESSED IN VIBRIO CHOLERAE

Ribaudo Giovanni, MULTI-TARGET NATURE-INSPIRED SMALL MOLECULES TO CONTRAST SARS-COV-2

 

Anti-inflammatory targets

Scalvini Laura, Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine Acid Amidase

Scognamiglio Antonia, HYBRIDS BETWEEN H2S-DONORS AND BETAMETHASONE 17-VALERATE OR TRIAMCINOLONE ACETONIDE: IN VITRO EFFECT IN ASTHMA TREATMENT

 

CNS

Basagni Filippo, INHIBITION OF β-AMYLOID AGGREGATION IN ALZHEIMER DISEASE: THE KEY ROLE OF PRO-ELETROPHILIC WARHEADS

Bavo Francesco, C(5)-SUBSTITUTED 2-(2-PYRROLIDINLYL) 1,4-BENZODIOXANES AS SELECTIVE α4β2 NICOTINIC ACETYLCHOLINE RECEPTOR PARTIAL AGONISTS

Bucolo Federica, INVESTIGATION ON PYRIDINYL-1,2,4-TRIAZOLE-BASED COMPOUNDS AS a-SYN AGGREGATION INHIBITORS FOR TREATING PARKINSON’S DISEASE

Esposito Gianluca, TOWARDS THE IDENTIFICATION OF THE BINDING SITE OF NEUROUNINA-1 TO ISOFORMS 1 AND 3 OF NCX: NEW INSIGHTS INTO STRUCTURE-ACTIVITY-RELATIONSHIP OF NCX MODULATORS

Grieco Ilenia, DEVELOPING NOVEL CLASSES OF PROTEIN KINASE CK1δ INHIBITORS BY FUSING [1,2,4]TRIAZOLE WITH DIFFERENT BICYCLIC HETEROAROMATIC SYSTEMS

Intagliata Sebastiano, NEW BENZYLPIPERAZINES AS SIGMA-1 RECEPTOR ANTAGONIST WITH PHARMACOLOGICAL EFFECTS IN MICE

Marotta Giambattista, DESIGN AND SYNTHESIS OF NEW MULTITARGET AGENTS FOR THE STUDY OF NEUROINFLAMMATION IN ALZEIMER’S DISEASE

Oselladore Erika, COMPUTATIONAL APPROACH TO THE INVESTIGATION OF NATURAL AND NATURE-INSPIRED COMPOUNDS FOR PHOSPHODIESTERASE INHIBITION

Rapetti Federica, NEW INSIGHT ON SELECTIVE PHOSPHODIESTERASE 4D (PDE4D) INHIBITORS

Romeo Isabella, RATIONAL DRUG DESIGN AND SYNTHESYS OF NEW thiophenE DERIVATIVES Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress

Rossino Giacomo, Dual Aquaporin and Sigma1 receptor modulators as innovative strategy to counteract oxidative stress and neurodegeneration

Salerno Alessandra, COMBINING RILUZOLE/DEXPRAMIPEXOLE AND RASAGILINE IN NEW MULTI-TARGET-DIRECTED LIGANDS IN THE CONTEXT OF AMYOTROPHIC LATERAL SCLEROSIS

Turnaturi Rita, Influence of the N-substituent of (-)-cis-N-Normetazocine in the modulation of the functional profile at MOR, DOR and KOR: from agonist to antagonist through multitarget agonist/ antagonist ligands

 

Computational approaches

Bufano Marianna, MODELING EPAC1 INTERACTIONS WITH THE ALLOSTERIC INHIBITOR AM-001 BY CO-SOLVENT MOLECULAR DYNAMICS

Galati Salvatore, MACHINE LEARNING PREDICTIONS OF ISOFORM-SELECTIVE CARBONIC ANHYDRASE INHIBITORS RATIONALIZED BY STRUCTURE-BASED ANALYSIS

Ravichandran Rahul, Application of docking strategies in the design of selective Carbonic Anhydrase I, II, IV, IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold

Ricci Federico, CROSSING LIGAND- AND STRUCTURE-BASED TECHNIQUES FOR IN SILICO RETRIEVING OF HCA VA INHIBITORS

Rondina Alessandro, ManXDR: A MANUALLY CURATED LIGAND DATABASE FOR DRUG REPOSITIONING

Uggeri Matteo, DOES NICOTINAMIDE COMBINES WITH LUMACAFTOR TO IMPROVE F508del-CFTR RESCUE?

 

Epigenetics

Cipriano Alessandra, DESIGN, SYNTHESIS, AND IN VITRO EVALUATION OF BIVALENT CHEMICAL PROBES TARGETING THE TANDEM BD1/BD2 IN BET PROTEINS

Iannelli Giulia, IDENTIFICATION OF NEW INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES BY A MULTI-SUBSTRATE-ADDUCT APPROACH

Sarno Giuliana, DEVELOPMENT AND APPLICATION OF A BIOPHYSICAL PLATFORM FOR THE IDENTIFICATION OF FRAGMENTS FOR THE DEVELOPMENT OF SETD8 LIGANDS

Viviano Monica, IDENTIFICATION OF NOVEL PYRAZOLE DERIVATIVES AS INHIBITORS OF LYSINE ACETYLTRANSFERASE P300

Oncology

Anceschi Lisa, RECENT ADVANCES IN THE ANTIPROLIFERATIVE ACTIVITY OF NON-PSYCHOACTIVE CANNABIS SATIVA L. EXTRACTS

Braconi Laura, NEW MULTITARGET COMPOUNDS: DUAL P-GP AND CA XII INHIBITORS TO REVERSE MULTIDRUG RESISTANCE IN CANCER CELLS

Culletta Giulia, Exploring the non-covalent ligand-binding mechanism on immunoproteasome by enhanced Molecular Dynamics

D'Amore Vincenzo, DISCOVERY OF NEW G4 STABILIZERS OF THE KRAS ONCOGENE: FROM VIRTUAL SCREENING CALCULATIONS TO BIOLOGICAL EVALUATION

De Leo Alessandro, DESIGN AND SYNTHESIS OF NEW PYRIMIDINE-BASED COMPOUNDS AS AURORA KINASE A INHIBITORS

Esposito Giovanna, SYNTHESIS AND ANTIPROLIFERATIVE EVALUATION OF SEROTONINERGIC LIGANDS

Failla Maria Cristina, A GENERATOR OF PEROXYNITRITE ACTIVABLE WITH RED LIGHT

Fallica Antonio, DESIGN, SYNTHESIS AND MOLECULAR MODELING STUDIES OF NOVEL HEME OXYGENASE-1 INHIBITORS WITH IN VITRO ANTIPROLIFERATIVE EFFECTS ON GLIOBLASTOMA

Ferlenghi Francesca, A LIPIDOMIC APPROACH TO DISCRIMINATE OSIMERTINIB SENSITIVE AND RESISTANT LUNG CANCER CELL LINES

Ialongo Davide, ANTI-TUMORAL EFFECTS OF A BENZIMIDAZOLYL CARBAMATE ESTER DERIVATIVE ON HEAD AND NECK SQUAMOUS CARCINOMA CELL LINES

Listro Roberta, DESIGN, SYNTHESIS AND ABSOLUTE CONFIGURATION OF NOVEL POTENTIAL γ-LACTAM SCAFFOLD FOR FIGHTING MULTIPLE MYELOMA

Marino Pasquale, Effects of Aloe barbadensis and Punica granatum extracts on 5-Fluorouracil-induced skin damage

Marino Pasquale, Ganoderma lucidum induce cell migration and injury prevention in human HaCaT cells

Marino Pasquale, Trifolium repens: new therapeutic agent active against CML

Nizi Maria Giulia, DISCOVERY OF SELECTIVE PARRP10 INHIBITORS AS POWERFUL TOOLS IN THE SEARCH FOR NEW ANTI-CANCER AGENTS

Pelliccia Sveva, DRUG-LIKE IMIDAZOPURINE DERIVATIVES AS G-QUADRUPLEX BINDERS VIA MULTICOMPONENT REACTIONS

Martino Elena, Design of new human Dihydroorotate Dehydrogenase inhibitors: amide bioisosterism in MEDS433 optimization

Sebastiani Jessica, A NEW POTENTIAL TARGET IN ONCOLOGICAL THERAPY: THE INTERACTION BETWEEN GAB2 WITH SH3-DOMAIN OF GBR2

Tagliazucchi Lorenzo, Targeting of the cysteines surface domain of the Transcription Enhancer Associate Domain (TEAD) for anticancer drug discovery

Vigiani Erica, 1,2,4-triazole: a “privileged” scaffold for the design of new inhibitors of the Enzime casein kinase 1δ

Vittorio Serena, In silico identification of small molecules as potential mTOR inhibitors targeting the rapamycin binding site

Synthetic approaches

Dimmito Marilisa, ON RESIN CLICK CHEMISTRY MEDIATED SYNTHESIS OF NOVEL ENKEPHALIN ANALOGUES WITH POTENT ANTINOCICEPTIVE ACTIVITY

Annunziata Francesca, TANDEM BIOCATALYTIC CONTINUOUS-FLOW SYNTHESIS OF HYDROXYTYROSOL AND OTHER TYROSOL METABOLITES

Berrino Emanuela, CARBONIC ANHYDRASE INHIBITORS WITH CARBON MONOXIDE RELEASING PROPERTIES: SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW POTENT ANTI-INFLAMMATORY AGENTS

Bonardi Alessandro, DEVELOPMENT OF H2S DONOR-CARBONIC ANHYDRASE INHIBITOR HYBRIDS FOR THE MANAGEMENT OF INFLAMMATION AND TUMORS

Cernicchi Giada, SCAFFOLD HOPPING APPROACH TO OBTAIN NEW AND POTENT S. aureus NorA EFFLUX PUMP INHIBITORS

Ciaffaglione Valeria, COMBINATION OF HEME OXYGENASE-1 INHIBITION AND SIGMA RECEPTOR AFFINITY FOR ANTICANCER ACTIVITY

Ciccone Lidia, A NATURAL PEPTIDE FROM BLACK MAMBA VENOM AS A SELECTIVE M2 RECEPTOR ANTAGONIST

Ferrisi Rebecca, MOLECULAR ALLIANCE: FROM ORTHOSTERIC AND ALLOSTERIC LIGANDS TO DUALSTERIC/BITOPIC AGONISTS AT CB2 RECEPTOR

Lusardi Matteo, HIGHLY-FUNTIONALIZED AMINO PYRAZOLES AS ANTIOXIDANT AGENTS: A PRELIMINARY SYNTHETIC ACCESSIBILITY STUDY

Mannella Iole, NEW INHIBITORS OF ALDO-KETO REDUCTASE 1C3 (AKR1C3) BASED ON BENZOISOXAZOLE SCAFFOLD AND THEIR POTENTIAL APPLICATION IN CANCER

Mazzotta Sarah, NOVEL DRIMANE-BASED TRPV4 ANTAGONISTS: DESIGN, SYNTHESIS AND IN VITRO EXPERIMENTAL VALIDATION

Mirabile Salvatore, ANALYSIS OF STRUCTURE-ACTIVITY RELATIONSHIPS IN A SERIES OF 4-(1-PIPERAZINYL)PHENOL-BASED DERIVATIVES AS COMPETITIVE INHIBITORS OF TYROSINASE

Nocentini Alessio, PHOSPHORUS-BASED MOTIFS FOR MEDICINAL CHEMISTRY PURPOSES: NOVEL APPLICATIONS AS CARBONIC ANHYDRASES INHIBITORS

Papotto Claudio, PHOTOSWITCHABLE LIGANDS FOR LIGHT-MEDIATED CONTROL OF α7 NICOTINIC ACETYLCHOLINE RECEPTORS: DESIGN, SYNTHESIS AND PHOTOCHROMIC CHARACTERIZATION

Barreca Marilia, EVALUATION OF FUSED PYRROLOTHIAZOLE SYSTEMS AS CORRECTORS OF MUTANT CFTR PROTEIN

Crocetti Letizia, Design and synthesis of the first indole-based blockers of Panx-1 channel

Ongaro Alberto, Targeting G-quadruplex DNA: synthesis of new ligands guided by ESI mass spectrometry and computational methods

Plescia Fabiana, THE ROLE OF A NEW PYRAZOLE STYRYLQUINAZOLINONE IN THE MODULATION OF CANNABINOIDERGIC SYSTEM

 

last update: 22-Apr-2021